直接用 SQL 修改：

USE [master]
GO
EXEC xp_instance_regwrite N'HKEY_LOCAL_MACHINE', N'Software\Microsoft\MSSQLServer\MSSQLServer', N'DefaultData', REG_SZ, N'F:\DataBase\SQLServer'
GO
EXEC xp_instance_regwrite N'HKEY_LOCAL_MACHINE', N'Software\Microsoft\MSSQLServer\MSSQLServer', N'DefaultLog', REG_SZ, N'F:\DataBase\SQLServer' 
GO